Klobenpropit je histaminski antagonist H3 receptora.[1] On ima neuroprotektivno dejstvo, koje ostvaruje putem stimulacije otpuštanja gama-aminobuterne kiseline u mozgu.[2]

Klobenpropit
IUPAC ime
N'-[(4-hlorofenil)metil]-1-[3-(3H-imidazol-4-il)propilsulfanil]formamidin
Identifikatori
CAS broj145231-45-4 ДаY
ATC kodnone
PubChemCID 2790
IUPHAR/BPS1223
ChemSpider2688
ChEMBLCHEMBL14690
Hemijski podaci
FormulaC14H17ClN4S
Molarna masa308,83 g/mol
  • C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl

Reference

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  1. ^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). „The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes”. Eur. J. Pharmacol. 567 (3): 206—10. PMID 17537431. doi:10.1016/j.ejphar.2007.04.032. 
  2. ^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613

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