S-14,671
S-14,671 je naftilpiperazinski derivat koji deluje kao agonist 5-HT1A receptora (pKi = 9.3) sa visokom efikasnošću i izuzetnom in vivo potencijom. On je isto tako antagonist 5-HT2A i 5-HT2C receptor (oba imaju pKi = 7.8).[1][2] On pokazuje samo nizak afinitet za 5-HT1B i 5-HT3 receptore.[2]
IUPAC ime | |
---|---|
N-{2-[4-(7-metoksinaftalen-1-il)piperazin-1-il]etil}tiofen-2-karboksamid | |
Identifikatori | |
CAS broj | 135722-27-9 |
ATC kod | none |
PubChem | CID 131907 |
ChemSpider | 116529 |
Hemijski podaci | |
Formula | C22H25N3O2S |
Molarna masa | 395,52 g/mol |
Reference
уреди- ^ Millan MJ, Canton H, Rivet JM, Lejeune F, Laubie M, Lavielle G (1991). „S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency”. European Journal of Pharmacology. 203 (2): 319—22. PMID 1839284. doi:10.1016/0014-2999(91)90734-8.
- ^ а б Millan MJ; Rivet JM; Canton H; et al. (1992). „S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors”. The Journal of Pharmacology and Experimental Therapeutics. 262 (2): 451—63. PMID 1323650.