6'''-Hidroksineomicin C oksidaza
6<nowiki>'”-hidroksineomicin C oksidaza (EC 1.1.3.44, neoG (gen)) je enzim sa sistematskim imenom 6<nowiki>'”-deamino-6<nowiki>'”-hidroksineomicin C:kiseonik 6<nowiki>'”-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 6<nowiki>'”-hidroksineomicin C oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.3.44 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 6<nowiki>'”-deamino-6<nowiki>'”-hidroksineomicin C + O2 6<nowiki>'”-deamino-6<nowiki>'”-oksoneomicin C +H2O2
Ovaj enzim sadrži FAD. On učestvuje u biosintetičkom putu aminoglikozidnih antibiotica iz neomicinske familije.
Reference уреди
- ^ Huang, F., Spiteller, D., Koorbanally, N.A., Li, Y., Llewellyn, N.M. and Spencer, J.B. (2007). „Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin”. ChemBioChem. 8: 283—288. PMID 17206729.
- ^ Clausnitzer, D., Piepersberg, W. and Wehmeier, U.F. (2011). „The oxidoreductases LivQ and NeoQ are responsible for the different 6′-modifications in the aminoglycosides lividomycin and neomycin”. J. Appl. Microbiol. 111: 642—651. PMID 21689223.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- -hydroxyneomycin%20C%20oxidase 6-hydroxyneomycin+C+oxidase на US National Library of Medicine Medical Subject Headings (MeSH)
