(3-Metil-2-oksobutanoat dehidrogenaza (acetil-transfer)) kinaza
(3-metil-2-oksobutanoat dehidrogenaza (acetil-transfer)) kinaza (EC 2.7.11.4, BCK, BCKD kinaza, BCODH kinaza, dehidrogenazna kinaza alfa-ketokiselina razgranatog lanca, dehidrogenazna kinaza 2-okso kiselina razgranatog lanca, dehidrogenazna kinaza keto kiselina razgranatog lanca, dehidrogenazna kinaza okso kiselina razgranatog lanca (fosforilacija), STK2) je enzim sa sistematskim imenom ATP:(3-metil-2-oksobutanoat dehidrogenaza (acetil-transfer)) fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (3-metil-2-oksobutanoat dehidrogenaza (acetil-transfer)) kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.4 | ||||||||
| CAS broj | 82391-38-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + [3-metil-2-oksobutanoat dehidrogenaza (acetil-transfer)] ADP + [3-metil-2-oksobutanoat dehidrogenaza (acetil-transfer)] fosfat
Ovaj enzim nema aktivirajuće jedinjenje ali je specifičan za svoj supstrat.
Reference
уреди- ^ Paxton, R. & Harris, R.A. (1982). „Isolation of rabbit liver branched chain α-ketoacid dehydrogenase and regulation by phosphorylation”. J. Biol. Chem. 257: 14433—14439. PMID 7142221.
- ^ Wynn, R.M., Chuang, J.L., Cote, C.D. and Chuang, D.T. (2000). „Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain α-ketoacid dehydrogenase kinase”. J. Biol. Chem. 275: 30512—30519. PMID 10903321.
- ^ Chuang, J.L., Wynn, R.M. and Chuang, D.T. (2002). „The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain α-keto acid dehydrogenase kinase”. J. Biol. Chem. 277: 36905—36908. PMID 12189132.
- ^ Popov, K.M., Hawes, J.W. and Harris, R.A. (1997). „Mitochondrial α-ketoacid dehydrogenase kinases: a new family of protein kinases”. Adv. Second Messenger Phosphoprotein Res. 31: 105—111. PMID 9344245.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- (3-methyl-2-oxobutanoate+dehydrogenase+(acetyl-transferring))+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
