(Metil-Co(III) metanol-specifični korinoid protein):koenzim M metiltransferaza
(Metil-Co(III) metanol-specifični korinoid protein):koenzim M metiltransferaza (EC 2.1.1.246, metiltransferaza 2, mtaA (gen)) je enzim sa sistematskim imenom korinoidni protein specifičan za metilisani metanol:koenzim M metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (Metil-Co(III) metanol-specifični korinoid protein):koenzim M metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.246 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- [metil-Co(III) metanol-specifični korinoidni protein] + koenzim M metil-KoM + [Co(I) metanol-specifični korinoidni protein]
Ovaj enzim učestvuje u metanogenezi metanola. On katalizuje transfer metil grupe sa korinoidnog proteina gde je vezana za kobaltni kofaktor, na koenzim M, čime se formira supstrat za EC 2.8.4.1, koenzim-B sulfoetiltiotransferazu, enzim koji katalizuje finalni korak metanogeneze.
Reference уреди
- ^ LeClerc, G.M. & Grahame, D.A. (1996). „Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression”. J. Biol. Chem. 271: 18725—18731. PMID 8702528.
- ^ Harms, U. & Thauer, R.K. (1996). „Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli”. Eur. J. Biochem. 235: 653—659. PMID 8654414.
- ^ Sauer, K. & Thauer, R.K. (1997). „Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction”. Eur. J. Biochem. 249: 280—285. PMID 9363780.
- ^ Sauer, K., Harms, U. and Thauer, R.K. (1997). „Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification, properties and encoding genes of the corrinoid protein MT1”. Eur. J. Biochem. 243: 670—677. PMID 9057830.
- ^ Sauer, K. & Thauer, R.K. (1999). „Methanol:coenzyme M methyltransferase from Methanosarcina barkeri – substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin”. Eur. J. Biochem. 261: 674—681. PMID 10215883.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- (methyl-Co(III)+methanol-specific+corrinoid+protein):coenzyme+M+methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
