(Metionin sintaza) reduktaza
(metionin sintaza) reduktaza (EC 1.16.1.8, metioninska sintaza kob(II)alaminska reduktaza (metilacija), metioninska sintaza reduktaza, (metioninska sintaza)-kobalaminska metiltransferaza (kob(II)alaminska redukcija)) je enzim sa sistematskim imenom (metionin sintaza)-metilkob(I)alamin,S-adenozilhomocistein:NADP+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (metionin sintaza) reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.16.1.8 | ||||||||
| CAS broj | 207004-87-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2 [metionin sintaza]-metilkob(I)alamin + 2 S-adenozilhomocistein + NADP+ 2 [metionin sintaza]-kob(II)alamin + NADPH + H+ + 2 S-adenozil-L-metionin
Kod ljudi je ovaj enzim flavoprotein koji sadrži FAD i FMN.
Reference уреди
- ^ Leclerc, D., Wilson, A., Dumas, R., Gafuik, C., Song, D., Watkins, D., Heng, H.H.Q., Rommens, J.M., Scherer, S.W., Rosenblatt, D.S., Gravel, R.A. (1998). „Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria”. Proc. Natl. Acad. Sci. USA. 95: 3059—3064. PMID 9501215.
- ^ Olteanu, H. & Banerjee, R. (2001). „Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation”. J. Biol. Chem. 276: 35558—35563. PMID 11466310.
- ^ Olteanu, H., Munson, T. and Banerjee, R. (2002). „Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase”. Biochemistry. 41: 13378—13385. PMID 12416982.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- (methionine+synthase)+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
