(N-acetilneuraminil)-galaktozilglukozilkeramid N-acetilgalaktozaminiltransferaza
(N-acetilneuraminil)-galaktozilglukozilkeramid N-acetilgalaktozaminiltransferaza (EC 2.4.1.92, uridin difosfoacetilgalaktozamin-gangliozid GM3 acetilgalaktozaminiltransferaza, gangliozid GM2 sintaza, gangliozid GM3 acetilgalaktozaminiltransferaza, GM2 sintaza, UDP acetilgalaktozamin-(N-acetilneuraminil)-D-galaktozil-D-glukozilkeramid acetilgalaktozaminiltransferaza, UDP-N-acetil-D-galaktozamin:1-O-(O-(N-acetil-alfa-neuraminil)-(2->3)-O-beta-D-galaktopiranozil-(1->4)-beta-D-glukopiranozil)-keramid 1,4-beta-N-acetil-D-galaktozaminiltransferaza acetilgalaktozaminiltransferaza, UDP-N-acetilgalaktozamin GM3 N-acetilgalaktozaminiltransferaza, uridin difosfoacetilgalaktozamin-acetilneuraminilgalaktozilglukozilkeramid acetilgalaktozaminiltransferaza, uridin difosfoacetilgalaktozamin-hematozid acetilgalaktozaminiltransferaza, GM2/GD2-sintaza, beta-1,4N-aetilgalaktozaminiltransferaza, asialo-GM2 sintaza, GalNAc-T, UDP-N-acetil-D-galaktozamin:(N-acetilneuraminil)-D-galaktozil-D-glukozilkeramid N-acetil-D-galaktozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-galaktozamin:1-O-(O-(N-acetil-alfa-neuraminil)-(2->3)-O-beta-D-galaktopiranosil-(1->4)-beta-D-glukopiranosil)-keramid 4-beta-N-acetil-D-galaktozaminiltransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (N-acetilneuraminil)-galaktozilglukozilkeramid N-acetilgalaktozaminiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.92 | ||||||||
| CAS broj | 67338-98-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- UDP-N-acetil-D-galaktozamin + 1-O-[O-(N-acetil-alfa-neuraminil)-(2->3)-O-beta-D-galaktopiranozil-(1->4)-beta-D-glukopiranozil]-keramid UDP + 1-O-[O-2-(acetilamino)-2-dezoksi-beta-D-galaktopiranozil-(1->4)-O-[N-acetil-alfa-neuraminil-(2->3)]-O-beta-D-galaktopiranozil-(1->4)-beta-D-glukopiranozil]-keramid
Ovaj enzim katalizuje formiranje gangliozida.
Reference
уреди- ^ Dicesare, J.L. & Dain, J.A. (1971). „The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)-galactosylglucosyl ceramide N-acetylgalactosaminyltransferase in rat brain”. Biochim. Biophys. Acta. 231: 385—393. PMID 5554906.
- ^ Pohlentz, G., Klein, D., Schwarzmann, G., Schmitz, D. and Sandhoff, K. (1988). „Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver”. Proc. Natl. Acad. Sci. USA. 85: 7044—7048. PMID 3140234.
- ^ Kazuya, I.-P., Hidari, J.K., Ichikawa, S., Furukawa, K., Yamasaki, M. and Hirabayashi, Y. (1994). „β1-4N-Acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a β1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F”. Biochem. J. 303: 957—965. PMID 7980468.
- ^ Hashimoto, Y., Sekine, M., Iwasaki, K. and Suzuki, A. (1993). „Purification and characterization of UDP-N-acetylgalactosamine GM3/GD3 N-acetylgalactosaminyltransferase from mouse liver”. J. Biol. Chem. 268: 25857—25864. PMID 8245020.
- ^ Nagai, K. & Ishizuka, I. (1987). „Biosynthesis of monosulfogangliotriaosylceramide and GM2 by N-acetylgalactosaminyltransferase from rat brain”. J. Biochem. (Tokyo). 101: 1115—1127. PMID 3115968.
- ^ Furukawa, K., Takamiya, K. and Furukawa, K. (2002). „β1,4-N-Acetylgalactosaminyltransferase—GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides”. Biochim. Biophys. Acta. 1573: 356—362. PMID 12417418.
- ^ Yamashita, T., Wu, Y.P., Sandhoff, R., Werth, N., Mizukami, H., Ellis, J.M., Dupree, J.L., Geyer, R., Sandhoff, K. and Proia, R.L. (2005). „Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions”. Proc. Natl. Acad. Sci. USA. 102: 2725—2730. PMID 15710896.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- (N-acetylneuraminyl)-galactosylglucosylceramide+N-acetylgalactosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
