3-Fenilpropionat dioksigenaza
3-Fenilpropionat dioksigenaza (EC 1.14.12.19, HcaA1A2CD, Hca dioksigenaza, 3-fenilpropionatna dioksigenaza) je enzim sa sistematskim imenom 3-fenilpropanoat,NADH:kiseonik oksidoreduktaza (2,3-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 3-Fenilpropionat dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.12.19 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (1) 3-fenilpropanoat + NADH + H+ + O2 3-(cis-5,6-dihidroksicikloheksa-1,3-dien-1-il)propanoat + NAD+
- (2) (2E)-3-fenilprop-2-enoat + NADH + H+ + O2 (2E)-3-(2,3-dihidroksifenil)prop-2-enoat + NAD+
Ovaj enzim učestvuje u degradaciji fenilpropanoidnih jedinjenja. On katalizuje umetanje oba atoma molekulskog kiseonika u pozicije 2 i 3 fenilnog prstena 3-fenilpropanoat ili (2E)-3-fenilprop-2-enoata.
Reference уреди
- ^ Díaz, E., Ferrández, A. and García, J.L. (1998). „Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12”. J. Bacteriol. 180: 2915—2923. PMID 9603882.
- ^ Burlingame, R. & Chapman, P.J. (1983). „Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli”. J. Bacteriol. 155: 113—121. PMID 6345502.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- 3-phenylpropanoate+dioxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
