Fosfoglukonat dehidrogenaza (dekarboksilacija)
(преусмерено са 6-fosfo-D-glukonatna dehidrogenaza)
Fosfoglukonat dehidrogenaza (dekarboksilacija) (EC 1.1.1.44, fosfoglukonska kiselina dehidrogenaza, 6-fosfoglukonska dehidrogenaza, 6-fosfoglukonska karboksilaza, 6-fosfoglukonatna dehidrogenaza (dekarboksilacija), 6-fosfo-D-glukonatna dehidrogenaza) je enzim sa sistematskim imenom 6-fosfo-D-glukonat:NADP+ 2-oksidoreduktaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fosfoglukonat dehidrogenaza (dekarboksilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 phosphogluconate dehydrogenase dimer, Sheep | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.44 | ||||||||
| CAS broj | 9073-95-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 6-fosfo-D-glukonat + NADP+ D-ribuloza 5-fosfat + CO2 + NADPH
Pojedini preparati redukuju NAD+, kao i NADP+.
Reference уреди
- ^ Dickens, F. & Glock, G.E. (1951). „Direct oxidation of glucose-6-phosphate, 6-phosphogluconate and pentose-5-phosphate by enzymes of animal origin”. Biochem. J. 50: 81—95. PMID 14904376.
- ^ Pontremoli, S., de Flora, A., Grazi, E., Mangiarotti, G., Bonsignore, A. and Horecker, B.L. (1961). „Purification and properties of β-L-hydroxy acid dehydrogenase. II. Isolation of β-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis”. J. Biol. Chem. 236: 2975—2980. PMID 14487824.
- ^ Scott, D.B.M. & Cohen, S.S. (1953). „The oxidative pathway of carbohydrate metabolism in Escherichia coli. 1. The isolation and properties of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase”. Biochem. J. 55: 23—33. PMID 13093611.
- ^ Scott, D.B.M. & Cohen, S.S. (1957). „The oxidative pathway of carbohydrate metabolism in Escherichia coli. 5. Isolation and identification of ribulose phosphate produced from 6-phosphogluconate by the dehydrogenase of E. coli”. Biochem. J. 65: 686—689. PMID 13426085.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Phosphogluconate+dehydrogenase+(decarboxylating) на US National Library of Medicine Medical Subject Headings (MeSH)
