Irazepin

Irazepin
IUPAC ime
	7-hloro-5-(2-fluorofenil)-1-(2-izotiocianatoetil)-3H-1,4-benzodiazepin-2-on
Identifikatori
CAS broj	71735-92-7
PubChem	CID 194406
ChemSpider	168688
Hemijski podaci
Formula	C18H13ClFN3OS
Molarna masa	373.83 g/mol
	SMILES C1C(=O)N(C2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CC=C3F)CCN=C=S; ;
	InChI InChI=1S/C18H13ClFN3OS/c19-12-5-6-16-14(9-12)18(13-3-1-2-4-15(13)20)22-10-17(24)23(16)8-7-21-11-25/h1-6,9H,7-8,10H2; Key:LTKSVYFAUMFQML-UHFFFAOYSA-N;

Irazepin (Ro 7-1986/1) je benzodiazepinski derivat koji sadrži izotiocijanatnu funkcionalnu grupu.^[1] On je nekompetitivni antagonist benzodiazepinskog mesta vezivanja.^[2] Irazepin i drugi alkilirajući benzodiazepin, kenazepin, se vezuju za moždane benzodiazepinske receptore u nekompetitivnom (kovalentnom) maniru in vitro, i mogu da imaju dugotrajni antikonvulsivni efekat.^[3]

Reference уреди

^ Edited by Ganellin, CR; Triggle, DJ (1999). Dictionary of Pharmacological Agents. (1st изд.). London: Chapman & Hall. ISBN 9780412466304.
^ Hall, Ian K.M. Morton, Judith M. (1999). Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. стр. 156. ISBN 978-94-011-4439-1.
^ Williams, EF; Rice, KC; Mattson, M; Paul, SM; Skolnick, P (1981). „In Vivo Effects of Two Novel Alkylating Benzodiazepines, Irazepine and Kenazepine”. Pharmacology, Biochemistry, and Behavior. 14 (4): 487—91. PMID 7232472. doi:10.1016/0091-3057(81)90307-5.