ADP-ribozilargininska hidrolaza
ADP-ribozilargininska hidrolaza (EC 3.2.2.19, enzim razlaganja ADP-riboza-L-arginina, Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza, protein-omega-N-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza) je enzim sa sistematskim imenom protein-Nomega-(ADP-D-ribozil)-L-arginin ADP-ribozilhidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| ADP-ribozilargininska hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.2.19 | ||||||||
| CAS broj | 98668-52-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (1) protein-Nomega-(ADP-D-ribozil)-L-arginin + H2O ADP-riboza + protein-L-arginin
- (2) Nomega-(ADP-D-ribozil)-L-arginin + H2O ADP-riboza + L-arginin
Ovaj enzim uklanja ADP-ribozu sa argininskih ostataka u ADP-ribozilisanim proteinima.
Reference уреди
- ^ Moss, J., Jacobson, M.K. and Stanley, S.J. (1985). „Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme”. Proc. Natl. Acad. Sci. USA. 82: 5603—5607. PMID 2994036.
- ^ Moss, J., Stanley, S.J., Nightingale, M.S., Murtagh, J.J., Jr., Monaco, L., Mishima, K., Chen, H.C., Williamson, K.C. and Tsai, S.C. (1992). „Molecular and immunological characterization of ADP-ribosylarginine hydrolases”. J. Biol. Chem. 267: 10481—10488. PMID 1375222.
- ^ Konczalik, P. & Moss, J. (1999). „Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases”. J. Biol. Chem. 274: 16736—16740. PMID 10358013.
- ^ Takada, T., Iida, K. and Moss, J. (1993). „Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase”. J. Biol. Chem. 268: 17837—17843. PMID 8349667.
- ^ Ohno, T., Tsuchiya, M., Osago, H., Hara, N., Jidoi, J. and Shimoyama, M. (1995). „Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase”. Anal. Biochem. 10: 115—122. PMID 8678289.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- (protein+ADP-ribosylarginine)+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
