AM-905

AM-905
IUPAC ime
	(6aR,9R,10aR)-3-[(E)-hept-1-enil]-9-(hidroksimetil)-6,6-dimetil-6a,7,8,9,10,10a-heksahidrobenzo[c]hromen-1-ol
Identifikatori
PubChem	CID 9998522
ChemSpider	8174103
ChEMBL	CHEMBL127848
Hemijski podaci
Formula	C23H34O3
Molarna masa	358,513 g/mol
	SMILES CCCCCC=Cc(cc1O)cc(OC(C)(C)C2CC3)c1C2CC3CO; ;
	InChI InChI=1S/C23H34O3/c1-4-5-6-7-8-9-16-13-20(25)22-18-12-17(15-24)10-11-19(18)23(2,3)26-21(22)14-16/h8-9,13-14,17-19,24-25H,4-7,10-12,15H2,1-3H3/b9-8+/t17-,18-,19-/m1/s1 ; Key:NJIKRWBGUIYKJM-OKMMTOMJSA-N ;

AM-905 je analgetik koji je kanabinoidni agonist sa konformaciono ograničenim bočnim lancom. On je potentan i relativno selektivan agonist CB₁ kanabinoidnog receptora, sa K_i od 1,2 nM na CB₁ i 5,3 nM naCB₂.^[1]

Reference

^ Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219

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[1] Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219

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