Kinaza hidroksimetilglutaril-KoA reduktaze NADPH
(преусмерено са AMP-aktivirana proteinska kinaza)
Kinaza hidroksimetilglutaril-KoA reduktaze NADPH (EC 2.7.11.31, AMPK, AMP-aktivirana proteinska kinaza, HMG-KoA reduktazna kinaza, beta-hidroksi-beta-metilglutaril-KoA reduktazna kinaza, (hidroksimetilglutaril-KoA reduktaza (NADPH2)) kinaza, 3-hidroksi-3-metilglutaril koenzim A reduktazna kinaza, 3-hidroksi-3-metilglutaril-KoA reduktazna kinaza, hidroksimetilglutaril koenzim A reduktazna kinaza, hidroksimetilglutaril koenzim A reduktazna kinaza (fosforilacija), hidroksimetilglutaril-KoA reduktazna kinaza, reduktazna kinaza, STK29) je enzim sa sistematskim imenom ATP:(hidroksimetilglutaril-KoA reduktaza (NADPH)) fosfotransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kinaza hidroksimetilglutaril-KoA reduktaze NADPH | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.7.11.31 | ||||||||
| CAS broj | 172522-01-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- ATP + [hidroksimetilglutaril-KoA reduktaza (NADPH)] ADP + [hidroksimetilglutaril-KoA reduktaza (NADPH)] fosfat
Ovaj enzim aktivira AMP.
Reference уреди
- ^ Beg, Z.H., Stonik, J.A. and Brewer, H.B., Jr. (1978). „3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation”. Proc. Natl. Acad. Sci. USA. 75: 3678—3682. PMID 278983.
- ^ Gibson, D.M. & Ingebritsen, T.S. (1978). „Reversible modulation of liver hydroxymethylglutaryl CoA reductase”. Life Sci. 23: 2649—2664. PMID 216867.
- ^ Ingebritsen, T.S., Lee, H.-S., Parker, R.A. and Gibson, D.M. (1978). „Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation”. Biochem. Biophys. Res. Commun. 81: 1268—1277. PMID 666819.
- ^ Ferrer, A., Caelles, C., Massot, N. and Hegardt, F.G. (1987). „Allosteric activation of rat liver microsomal [hydroxymethylglutaryl-CoA reductase (NADPH)]kinase by nucleoside phosphates”. Biol. Chem. Hoppe Seyler. 368: 249—257. PMID 3689494.
- ^ Weekes, J., Ball, K.L., Caudwell, F.B. and Hardie, D.G. (1993). „Specificity determinants for the AMP-activated protein kinase and its plant homologue analysed using synthetic peptides”. FEBS Lett. 334: 335—339. PMID 7902296.
- ^ Crute, B.E., Seefeld, K., Gamble, J., Kemp, B.E. and Witters, L.A. (1998). „Functional domains of the a1 catalytic subunit of the AMP-activated protein kinase”. J. Biol. Chem. 273: 35347—35354. PMID 9857077.
- ^ Stein, S.C., Woods, A., Jones, N.A., Davison, M.D. and Carling, D. (2000). „The regulation of AMP-activated protein kinase by phosphorylation”. Biochem. J. 345: 437—443. PMID 10642499.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- (hydroxymethylglutaryl-CoA+reductase+(NADPH))+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
