Acil-KoA dehidrogenaza srednje dugog lanca
Acil-KoA dehidrogenaza srednje dugog lanca (EC 1.3.8.7, masna acil koenzim A dehidrogenaza (nespecifična), acil koenzim A dehidrogenaza (nespecifična), acil dehidrogenaza (nespecifična), masna-acil-KoA dehidrogenaza (nespecifična), acil KoA dehidrogenaza (nespecifična), general acil KoA dehidrogenaza (nespecifična), acil-koenzim A dehidrogenaza srednje dugog lanca, acil-KoA:(akceptor) 2,3-oksidoreduktaza (nespecifična), ACADM (gen).) je enzim sa sistematskim imenom acil-KoA srednje dugog lanca:elektron-transfer flavoprotein 2,3-oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Acil-KoA dehidrogenaza srednje dugog lanca | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Acil-KoA dehidrogenaza srednje dugog lanca tetramer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.8.7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- acil-KoA srednje dugog lanca + elektron-transfer flavoprotein trans-2,3-dehidroacil-KoA srednje dugog lanca + redukovani elektron-transfer flavoprotein
Ovaj enzim sadrži FAD kao prostetičku grupu. On je jedan od nekoliko enzima koji katalizuju prvi korak u beta oksidaciji masnih kiselina. Enzim iz jetre svinja može da deluje na supstrat sa acil lancom dožine 4 do 16 ugljenika, ali je najaktivniji na jedinjenjima sa C8 do C12 dugim lancom.
Reference уреди
- ^ Crane, F.L., Hauge, J.G. and Beinert, H. (1955). „Flavoproteins involved in the first oxidative step of the fatty acid cycle”. Biochim. Biophys. Acta. 17: 292—294. PMID 13239683.
- ^ Crane, F.L., Mii, S., Hauge, J.G., Green, D.E. and Beinert, H. (1956). „On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. I. The general fatty acyl coenzyme A dehydrogenase”. J. Biol. Chem. 218: 701—716. PMID 13295224.
- ^ Beinert, H. (1963). „Acyl coenzyme A dehydrogenase”. Ур.: Boyer, P.D., Lardy, H.; Myrb; auml; ck, K. The Enzymes. 7 (2nd изд.). New York: Academic Press. стр. 447—466.
- ^ Ikeda, Y., Ikeda, K.O. and Tanaka, K. (1985). „Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme”. J. Biol. Chem. 260: 1311—1325. PMID 3968063.
- ^ Thorpe, C. & Kim, J.J. (1995). „Structure and mechanism of action of the acyl-CoA dehydrogenases”. FASEB J. 9: 718—725. PMID 7601336.
- ^ Kim, J.J., Wang, M. and Paschke, R. (1993). „Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate”. Proc. Natl. Acad. Sci. USA. 90: 7523—7527. PMID 8356049.
- ^ Peterson, K.L., Sergienko, E.E., Wu, Y., Kumar, N.R., Strauss, A.W., Oleson, A.E., Muhonen, W.W., Shabb, J.B. and Srivastava, D.K. (1995). „Recombinant human liver medium-chain acyl-CoA dehydrogenase: purification, characterization, and the mechanism of interactions with functionally diverse C8-CoA molecules”. Biochemistry. 34: 14942—14953. PMID 7578106.
- ^ Toogood, H.S., van Thiel, A., Basran, J., Sutcliffe, M.J., Scrutton, N.S. and Leys, D. (2004). „Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex”. J. Biol. Chem. 279: 32904—32912. PMID 15159392.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Medium-chain+acyl-CoA+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
