Antranilat fosforiboziltransferaza
Antranilat fosforiboziltransferaza (EC 2.4.2.18, fosforibozil-antranilat pirofosforilaza, PRT, antranilat 5-fosforibozilpirofosfat fosforiboziltransferaza, antranilat fosforibozilpirofosfat fosforiboziltransferaza, fosforibozilantranilat pirofosforilaza, fosforibozilantranilat transferaza, antranilat-PP-riboza-P fosforiboziltransferaza) je enzim sa sistematskim imenom N-(5-fosfo-D-ribozil)-antranilat:difosfat fosfo-alfa-D-riboziltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Antranilat fosforiboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.2.18 | ||||||||
| CAS broj | 9059-35-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- N-(5-fosfo-D-ribozil)-antranilat + difosfat antranilat + 5-fosfo-alfa-D-riboza 1-difosfat
Kod pojedinih organizama, ovaj enzim je deo multifunkcionalnog proteina zajedno sa jednom ili više komponenti sistema za biosintezu triptofana, cf. EC 4.1.1.48 (indol-3-glicerol-fosfat sintaza), EC 4.1.3.27 (antranilat sintaza), EC 4.2.1.20 (triptofan sintaza) i EC 5.3.1.24 (fosforibozilantranilat izomeraza).
Reference уреди
- ^ Creighton, T.E. & Yanofsky, C. (1970). „Chorismate to tryptophan (Escherichia coli) - anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan synthetase”. Methods Enzymol. 17A: 365—380.
- ^ Hütter, R., Niederberger, P. and DeMoss, J.A. (1986). „Tryptophan synthetic genes in eukaryotic microorganisms”. Annu. Rev. Microbiol. 40: 55—77. PMID 3535653.
- ^ Ito, J. & Yanofsky, C. (1969). „Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits”. J. Bacteriol. 97: 734—742. PMID 4886290.
- ^ Wegman, J. & DeMoss, J.A. (1965). „The enzymatic conversion of anthranilate to indolylglycerol phosphate in Neurospora crassa”. J. Biol. Chem. 240: 3781—3788. PMID 5842052.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Anthranilate+phosphoribosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
