Antraniloil-KoA monooksigenaza
Antraniloil-KoA monooksigenaza (EC 1.14.13.40, antraniloil koenzim A reduktaza, 2-aminobenzoil-KoA monooksigenaza/reduktaza) je enzim sa sistematskim imenom 2-aminobenzoil-KoA,NAD(P)H:kiseonik oksidoreduktaza (dearomatizacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Antraniloil-KoA monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.40 | ||||||||
| CAS broj | 112692-57-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2-aminobenzoil-KoA + 2 NAD(P)H + 2 H+ + O2 2-amino-5-oksocikloheks-1-enkarboksil-KoA + H2O + 2 NAD(P)+
Ovaj enzim je flavoprotein (FAD). Nearomatični produkt je nestavilan i oslobađa se CO2 i NH3, čime se formira 1,4-cikloheksandion.
Reference уреди
- ^ Buder, R. & Fuchs, G. (1989). „2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Purification and some properties of the enzyme”. Eur. J. Biochem. 185: 629—635. PMID 2591379.
- ^ Buder, R., Ziegler, K., Fuchs, G., Langkau, B. and Ghisla, S. (1989). „2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Studies on the stoichiometry and the course of the reaction”. Eur. J. Biochem. 185: 637—643. PMID 2591380.
- ^ Langkau, B., Ghisla, S., Buder, R., Ziegler, K. and Fuchs, G. (1990). „2-Aminobenzoyl-CoA monooxygenase/reductase, a novel type of flavoenzyme. Identification of the reaction products”. Eur. J. Biochem. 191: 365—371. PMID 2384085.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Anthraniloyl-CoA+monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
