Atazanavir je organsko jedinjenje, koje sadrži 38 atoma ugljenika i ima molekulsku masu od 704,856 Da.[1][2][3][4][5][6][7]

Atazanavir
Atazanavir-skeletal.svg
Atazanavir ball-and-stick.png
Klinički podaci
Prodajno imeLatazanavir, Reyataz, Zrivada
Drugs.comMonografija
Način primeneOralno
Farmakokinetički podaci
Poluvreme eliminacije7 h
Identifikatori
CAS broj198904-31-3 ДаY
ATC kodJ05AE08 (WHO)
PubChemCID 148192
DrugBankDB01072 ДаY
ChemSpider130642 ДаY
ChEBICHEBI:37924 ДаY
ChEMBLCHEMBL1163 ДаY
Hemijski podaci
FormulaC38H52N6O7
Molarna masa704,856

OsobineУреди

Osobina Vrednost
Broj akceptora vodonika 9
Broj donora vodonika 5
Broj rotacionih veza 18
Particioni koeficijent[8] (ALogP) 4,7
Rastvorljivost[9] (logS, log(mol/L)) -9,6
Polarna površina[10] (PSA, Å2) 171,2

ReferenceУреди

  1. ^ Croom KF, Dhillon S, Keam SJ: Atazanavir: a review of its use in the management of HIV-1 infection. Drugs. 2009 May 29;69(8):1107-40. doi: 10.2165/00003495-200969080-00009. PMID 19496633
  2. ^ von Hentig N: Atazanavir/ritonavir: a review of its use in HIV therapy. Drugs Today (Barc). 2008 Feb;44(2):103-32. PMID 18389089
  3. ^ Swainston Harrison T, Scott LJ: Atazanavir: a review of its use in the management of HIV infection. Drugs. 2005;65(16):2309-36. PMID 16266202
  4. ^ Le Tiec C, Barrail A, Goujard C, Taburet AM: Clinical pharmacokinetics and summary of efficacy and tolerability of atazanavir. Clin Pharmacokinet. 2005;44(10):1035-50. PMID 16176117
  5. ^ Lopez-Cortes LF: [Pharmacology, pharmacokinetic features and interactions of atazanavir] Enferm Infecc Microbiol Clin. 2008 Dec;26 Suppl 17:2-8. PMID 20116610
  6. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  7. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 
  8. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  9. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  10. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

LiteraturaУреди

Spoljašnje vezeУреди

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