Atrolizin-A
Atrolizin-A (EC 3.4.24.1, Crotalus atrox metaloendopeptidaza a, hemoragijski toksin a, Crotalus atrox alfa-proteinaza, Crotalus atrox proteinaza, botropajin) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Atrolizin-A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.1 | ||||||||
| CAS broj | 37288-82-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Odvajanje Asn3-Gln, His5-Leu, His10-Leu, Ala14-Leu i Tyr16-Leu u insulinskom B lancu. Uklanjanje C-terminalnog Leu sa malih peptida
Ova hemoragijska endopeptidaza je jedna od šest hemoragijskih toksina u venomu zvečarke Crotalus atrox.
Reference уреди
- ^ Bjarnason, J.B. & Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry. 17: 3395—3404. PMID 210790.
- ^ Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. (1987). „Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from 'Crotalus ruber ruber venom”. Arch. Biochem. Biophys. 253: 108—121. PMID 2949699.
- ^ Bjarnason, J.B., Hamilton, D. and Fox, J.W. (1988). „Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom”. Biol. Chem. Hoppe-Seyler. 369: 121—129. PMID 3060135.
- ^ Bjarnason, J.B. & Fox, J.W. (1989). „Hemorrhagic toxins from snake venoms”. J. Toxicol. Toxin Rev. 7: 121—209.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Atrolysin+A на US National Library of Medicine Medical Subject Headings (MeSH)
