Atrolizin E
Atrolizin E (EC 3.4.24.44, Crotalus atrox metaloendopeptidaza e, hemoragi, ni toksin e) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Atrolizin E | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.44 | ||||||||
| CAS broj | 172306-51-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Razlaganje Asn3-Gln, Ser9-His i Ala14-Leu veza u lancu insulina B i Tyr14-Gln i Thr8-Ser u A lancu. Razlaganje tipa IV kolagena na Ala73-Gln u alfa1(IV) i na Gly7-Leu u alfa2(IV)
Ova nehemoragična endopeptidaza je prisutna u venumu zvečarke Crotalus atrox.
Reference
уреди- ^ Bjarnason, J.B. & Tu, A.T. (1978). „Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e”. Biochemistry. 17: 3395—3404. PMID 210790.
- ^ Bjarnason, J.B. & Fox, J.W. (1983). „Proteolytic specificity and cobalt exchange of hemorrhagic toxin e, a zinc protease isolated from the venom of the western diamondback rattlesnake (Crotalus atrox)”. Biochemistry. 22: 3770—3778. PMID 6351911.
- ^ Baramova, E.N., Shannon, J.D., Bjarnason, J.B. and Fox, J.W. (1990). „Identification of the cleavave sites by a hemorrhagic metalloproteinase in type IV collagen”. Matrix. 10: 91—97. PMID 2374521.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Atrolysin+E на US National Library of Medicine Medical Subject Headings (MeSH)
