Memapsin 2
(преусмерено са Beta-sekretaza 1)
Memapsin 2 (EC 3.4.23.46, beta-sekretaza, enzim 1 razlaganja beta-mesta Alchajmerovog amiloidnog prekursornog proteina, BACE1) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Memapsin 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.23.46 | ||||||||
| CAS broj | 158736-49-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Široka endopeptidazna specifičnost. Razlaže se Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe u švedkoj varijanti Alchajmerovog amiloidnog prekursornog proteina
Ovaj enzim pripada peptidaznoj familiji A1.
Reference уреди
- ^ Turner, R.T., III, K oelsch, G., Hong, L., Castenheira, P., Ghosh, A. and Tang, J. (2001). „Subsite specificity of memapsin 2 (β-secretase): implications for inhibitor design”. Biochemistry. 40: 10001—10006. PMID 11513577.
- ^ Hong, L., Turner, R.T., Koelsch, G., Shin, D., Ghosh, A.K. and Tang, J. (2002). „Crystal structure of memapsin 2 (β-secretase) in complex with an inhibitor OM00-3”. Biochemistry. 41: 10963—10967. PMID 12206667.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Memapsin+2 на US National Library of Medicine Medical Subject Headings (MeSH)
