Biotin sintaza
Biotin sintaza (EC 2.8.1.6, Biotin synthase) je enzim sa sistematskim imenom detiobiotin:sumpor sumportransferaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Biotin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.1.6 | ||||||||
| CAS broj | 80146-93-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- detiobiotin + [S] + 2 S-adenozil-L-metionin biotin + 2 L-metionin + 2 5'-dezoksiadenozin
Ovaj enzim vezuje [4Fe-4S] i [2Fe-2S] klaster.
Reference уреди
- ^ Trainor, D.A., Parry, R.J. and Gitterman, A. (1980). „Biotin biosynthesis. 2. Stereochemistry of sulfur introduction at C-4 of dethiobiotin”. J. Am. Chem. Soc. 102: 1467—1468.
- ^ Shiuan, D. & Campbell, A. (1988). „Transcriptional regulation and gene arrangement of Escherichia coli, Citrobacter freundii and Salmonella typhimurium biotin operons”. Gene. 67: 203—211. PMID 2971595.
- ^ Zhang, S., Sanyal, I., Bulboaca, G.H., Rich, A. and Flint, D.H. (1994). „The gene for biotin synthase from Saccharomyces cerevisiae: cloning, sequencing, and complementation of Escherichia coli strains lacking biotin synthase”. Arch. Biochem. Biophys. 309: 29—35. PMID 8117110.
- ^ Ugulava, N.B., Gibney, B.R. and Jarrett, J.T. (2001). „Biotin synthase contains two distinct iron-sulfur cluster binding sites: chemical and spectroelectrochemical analysis of iron-sulfur cluster interconversions”. Biochemistry. 40: 8343—8351. PMID 11444981.
- ^ Berkovitch, F., Nicolet, Y., Wan, J.T., Jarrett, J.T. and Drennan, C.L. (2004). „Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme”. Science. 303: 76—79. PMID 14704425.
- ^ Lotierzo, M., Tse Sum Bui, B., Florentin, D., Escalettes, F. and Marquet, A. (2005). „Biotin synthase mechanism: an overview”. Biochem. Soc. Trans. 33: 820—823. PMID 16042606.
- ^ Taylor, A.M., Farrar, C.E. and Jarrett, J.T. (2008). „9-Mercaptodethiobiotin is formed as a competent catalytic intermediate by Escherichia coli biotin synthase”. Biochemistry. 47: 9309—9317. PMID 18690713.
- ^ Reyda, M.R., Fugate, C.J. and Jarrett, J.T. (2009). „A complex between biotin synthase and the iron-sulfur cluster assembly chaperone HscA that enhances in vivo cluster assembly”. Biochemistry. 48: 10782—10792. PMID 19821612.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Biotin+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
