DNK nukleotidileksotransferaza
DNK nukleotidileksotransferaza (EC 2.7.7.31, terminal dezoksiribonukleotidiltransferaza, terminal addition enzim, addase, dezoksinukleotidil terminal transferaza, dezoksiribonukleinska kiselina nukleotidiltransferaza, dezoksiribonukleinska nukleotidiltransferaza, terminal dezoksinukleotid transferaza, TdT) je enzim sa sistematskim imenom nukleozid-trifosfat:DNK dezoksinukleotidileksotransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| DNK nukleotidileksotransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.7.7.31 | ||||||||
| CAS broj | 9027-67-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- dezoksinukleozid trifosfat + DNKn difosfat + DNKn+1
Ovaj enzim katalizuje od okvira nezavisno produžavanje 3'-kraja DNK lanca.
Reference уреди
- ^ Bollum, F.J. (1971). „Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase”. J. Biol. Chem. 246: 909—916. PMID 5543689.
- ^ Gottesman, M.E. & Canellakis, E.S. (1966). „The terminal nucleotidyltransferases of calf thymus nuclei”. J. Biol. Chem. 241: 4339—4352. PMID 4288534.
- ^ Krakow, J.S., Coutsogeorgopoulos, C. and Canellakis, E.S. (1962). „Studies on the incorporation of deoxyribonucleic acid”. Biochim. Biophys. Acta. 55: 639—650. PMID 14459258.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- DNA+nucleotidylexotransferase на US National Library of Medicine Medical Subject Headings (MeSH)
