Dimetilamin-korinoid protein Co-metiltransferaza
Dimetilamin-korinoid protein Co-metiltransferaza (EC 2.1.1.249, mtbB (gen), dimetilaminska metiltransferaza) je enzim sa sistematskim imenom dimetilamin:5-hidroksibenzimidazolilkobamid Co-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Dimetilamin-korinoid protein Co-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.249 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- dimetilamin + [Co(I) dimetilamin-specifični korinoidni protein] [metil-Co(III) dimetilamin-specifični korinoidni protein] + metilamin
Enzim, koji katalizuje transfer metil grupe sa dimetilamina na dimetilamin-specifični korinoidni protein (MtbC), učestvuje u metanogenezi. Ovaj enzim sadrži neobičnu aminokiselinu pirolizin.
Reference
уреди- ^ Wassenaar, R.W., Keltjens, J.T., van der Drift, C. and Vogels, G.D. (1998). „Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro”. Eur. J. Biochem. 253: 692—697. PMID 9654067.
- ^ Ferguson, D.J., Jr., Gorlatova, N., Grahame, D.A. and Krzycki, J.A. (2000). „Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri”. J. Biol. Chem. 275: 29053—29060. PMID 10852929.
- ^ Krzycki, J.A. (2004). „Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases”. Curr. Opin. Chem. Biol. 8: 484—491. PMID 15450490.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Dimethylamine---corrinoid+protein+Co-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
