Arogenat dehidrogenaza (NADP+)
(преусмерено са EC 1.3.1.78)
Arogenat dehidrogenaza (NADP+) (EC 1.3.1.78, arogenatna dehidrogenaza (nespecifična), pretirozinska dehidrogenaza (nespecifična), TyrAAT1, TyrAAT2, TyrAa) je enzim sa sistematskim imenom L-arogenat:NADP+ oksidoreduktaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Arogenat dehidrogenaza (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.78 | ||||||||
| CAS broj | 64295-75-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-arogenat + NADP+ L-tirozin + NADPH + CO2
Za razliku od EC 1.3.1.43 (arogenat dehidrogenaze) i EC 1.3.1.79 [arogenat dehidrogenaze (NAD(P)+)], ovaj enzim enzim koristi samo NADP+. Enzim iz Synechocystis sp. PCC 6803 i izoforme TyrAAT1 ne može da koristi prefenat kao supstrat, dok izoforma TyrAAT2 može da ga koristi, mada veome slabo.
Reference
уреди- ^ Byng, G., Whitaker, R., Flick, C. and Jensen, R.A. (1981). „Enzymology of L-tyrosine biosynthesis in corn (Zea mays)”. Phytochemistry. 20: 1289—1292.
- ^ Gaines, C.G., Byng, G.S., Whitaker, R.J. and Jensen, R.A. (1982). „L-Tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes”. Planta. 156: 233—240.
- ^ Rippert, P. & Matringe, M. (2002). „Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana”. Eur. J. Biochem. 269: 4753—4761. PMID 12354106.
- ^ Bonner, C.A., Jensen, R.A., Gander, J.E. and Keyhani, N.O. (2004). „A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis”. Biochem. J. 382: 279—291. PMID 15171683.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Arogenate+dehydrogenase+(NADP+) на US National Library of Medicine Medical Subject Headings (MeSH)
