TRNK (guanin26-N2/guanin27-N2)-dimetiltransferaza
(преусмерено са EC 2.1.1.215)
TRNK (guanin26-N2/guanin27-N2)-dimetiltransferaza (EC 2.1.1.215, Trm1, tRNK (N2,N2-guanin)-dimetiltransferaza, tRNK (m2(2)G26) metiltransferaza, Trm1(tRNK (m2(2)G26) metiltransferaza)) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin26-N2/guanin27-N2)-dimetiltransferaza.[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| TRNK (guanin26-N2/guanin27-N2)-dimetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.215 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 4 S-adenozil-L-metionin + guanin26/guanin27 u tRNK 4 S-adenozil-L-homocistein + N2-dimetilguanin26/N2-dimetilguanin27 u tRNK
Enzim iz Aquifex aeolicus je sličan sa TRM1 metiltransferazama iz arheja i eukariota (cf. EC 2.1.1.216, tRNK (guanin26-N2)-dimetiltransferaza). Međutim, on katalizuje dvostruku metilaciju guanina u pozicijama 26 i 27 tRNK.
Reference уреди
- ^ Awai, T., Kimura, S., Tomikawa, C., Ochi, A., Ihsanawati, Bessho, Y., Yokoyama, S., Ohno, S., Nishikawa, K., Yokogawa, T., Suzuki, T. and Hori, H. (2009). „Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA”. J. Biol. Chem. 284: 20467—20478. PMID 19491098.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- TRNA+(guanine26-N2/guanine27-N2)-dimethyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
