Kalpain-2
(преусмерено са EC 3.4.22.53)
Kalpain-2 (EC 3.4.22.53, kalcijumom aktivirana neutralna proteaza II, m-kalpain, mili-kalpain) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kalpain-2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.53 | ||||||||
| CAS broj | 702693-80-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Endopeptidazno dejstvo sa širokom specifičnošću
Ovaj enzim pripada familiji C2 peptidaza.
Reference
уреди- ^ Strobl, S., Fernandez-Catalan, C., Braun, M., Huber, R., Masumoto, H., Nakagawa, K., Irie, A., Sorimachi, H., Bourenkow, G., Bartunik, H., Suzuki, K. and Bode, W. (2000). „The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium”. Proc. Natl. Acad. Sci. USA. 97: 588—592. PMID 10639123.
- ^ Dutt, P., Spriggs, C.N., Davies, P.L., Jia, Z. and Elce, J.S. (2002). „Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain”. Biochem. J. 367: 263—269. PMID 12014988.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
