Endotiapepsin
(преусмерено са EC 3.4.23.22)
Endotiapepsin (EC 3.4.23.22, Endothia aspartinska proteinaza, Endothia kiselinska proteinaza, Endothia parasitica kiselinska proteinaza, Endothia parasitica aspartinsk proteinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Endotiapepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.22 | ||||||||
| CAS broj | 37205-60-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza proteina sa specifičnošću sličnom pepsinu A. Postoji preferencija za hidrofobne ostatake u P1 i P1'. Ne dolazi do razlaganja Ala14-Leu u B lancu insulina ili Z-Glu-Tyr. Dolazi do zgrušavanja mlaka
Ovaj enzim je prisutan u askomiceti Endothia parasitica.
Reference уреди
- ^ Whitaker, J.R. (1970). „Protease of Endothia parasitica”. Methods Enzymol. 19: 436—445.
- ^ Williams, D.C., Whitaker, J.R. and Caldwell, P.V. (1972). „Hydrolysis of peptide bonds of the oxidized B-chain of insulin by Endothia parasitica protease”. Arch. Biochem. Biophys. 149: 52—61. PMID 4552802.
- ^ Barkholt, V. (1987). „Amino acid sequence of endothiapepsin. Complete primary structure of the aspartic protease from Endothia parasitica”. Eur. J. Biochem. 167: 327—338. PMID 3305016.
- ^ Cooper, J., Foundling, S., Hemmings, A., Blundell, T., Jones, D.M., Hallett, A. and Szelke, M. (1987). „The structure of a synthetic pepsin inhibitor complexed with endothiapepsin”. Eur. J. Biochem. 169: 215—221. PMID 3119339.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Endothiapepsin на US National Library of Medicine Medical Subject Headings (MeSH)
