Peptidaza mitohondrijalna prerade
(преусмерено са EC 3.4.24.64)
Peptidaza mitohondrijalna prerade (EC 3.4.24.64, proteinaza transofmacije mitohondrijskog proteinskog prekursora, matriks peptidaza, matriks procesujuća peptidaza, matriks procesujuća proteinaza, proteinaza transformacije mitohondrijskog proteinskog prekursora, MPP) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Peptidaza mitohondrijalna prerade | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.24.64 | ||||||||
CAS broj | 86280-61-7 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Oslobađanje N-terminalnog ciljnih peptida sa prekursornih proteina unesenih u mitohondrion, tipično sa Arg u poziciji P2
Ovaj enzim je prisutan u mitohondrijskom matriksu gljiva i sisara.
Reference уреди
- ^ Jensen, R.E. & Yaffe, M.P. (1988). „Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit”. EMBO J. 7: 3863—3871. PMID 3061808.
- ^ Witte, C., Jensen, R.E., Yaffe, M.P. and Schatz, G. (1988). „MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease”. EMBO J. 7: 1439—1447. PMID 3044780.
- ^ Rawlings, N.D. & Barrett, A.J. (1991). „Homologues of insulinase, a new superfamily of metalloendopeptidases”. Biochem. J. 275: 389—391. PMID 2025223.
- ^ Kalousek, F., Neupert, W., Omura, T., Schatz, G. and Schmitz, U.K. (1993). „Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins”. Trends Biochem. Sci. 18: 249—249. PMID 8212133.
- ^ Brunner, M. & Neupert, W. (1994). „Purification and characterization of the mitochondrial processing peptidase of Neurospora crassa”. Methods Enzymol. 248: 717—728.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Mitochondrial+processing+peptidase на US National Library of Medicine Medical Subject Headings (MeSH)