GTPaza proteinske sinteze
(преусмерено са EC 3.6.5.3)
GTPaza proteinske sinteze (EC 3.6.5.3, elongacioni faktor (EF), inicijacioni faktor (IF), faktor peptidnog oslobađanja ili terminacije) je enzim sa sistematskim imenom GTP fosfohidrolaza (pomoć pri iRNK translaciji).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
GTPaza proteinske sinteze | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifikatori | |||||||||
EC broj | 3.6.5.3 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
|
- GTP + H2O GDP + fosfat
Ova grupa enzima pripada familiji proteina koji učestvuju u prokariotskoj, kao i u eukariotskoj, proteinskoj sintezi.
Reference
уреди- ^ Kurzchalia, T.V., Bommer, U.A., Babkina, G.T. and Karpova, G.G. (1984). „GTP interacts with the γ-subunit of eukaryotic initiation factor EIF-2”. FEBS Lett. 175: 313—316. PMID 6566615.
- ^ Kisselev, L.L. & Frolova, L.Yu. (1995). „Termination of translation in eukaryotes”. Biochem. Cell Biol. 73: 1079—1086. PMID 8722024.
- ^ Rodnina, M.V., Savelsberg, A., Katunin, V.I. and Wintermeyer, W. (1997). „Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome”. Nature. 385: 37—41. PMID 8985244.
- ^ Freistroffer, D.V., Pavlov, M.Y., MacDougall, J., Buckingham, R.H. and Ehrenberg, M. (1997). „Release factor RF3 in E. coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner”. EMBO J. 16: 4126—4133. PMID 9233821.
- ^ Krab, I.M. & Parmeggiani, A. (1998). „EF-Tu, a GTPase odyssey”. Biochim. Biophys. Acta. 1443: 1—22. PMID 9838020.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Protein-synthesizing+GTPase на US National Library of Medicine Medical Subject Headings (MeSH)