5-(Karboksiamino)imidazol ribonukleotidna sintaza
(преусмерено са EC 6.3.4.18)
5-(Karboksiamino)imidazol ribonukleotidna sintaza (EC 6.3.4.18, N5-CAIR sintetaza, N5-karboksiaminoimidazol ribonukleotidna sintetaza, PurK) je enzim sa sistematskim imenom 5-amino-1-(5-fosfo-D-ribozil)imidazol:ugljen-dioksid ligaza (formira ADP).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 5-(Karboksiamino)imidazol ribonukleotidna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.4.18 | ||||||||
| CAS broj | 255379-40-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + 5-amino-1-(5-fosfo-D-ribozil)imidazol + HCO3- ADP + fosfat + 5-karboksiamino-1-(5-fosfo-D-ribozil)imidazol
Kod Escherichia coli, ovaj enzim je neophodan za odvijanje reakcije enzima EC 4.1.1.21.
Reference уреди
- ^ Meyer, E., Leonard, N.J., Bhat, B., Stubbe, J. and Smith, J.M. (1992). „Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway”. Biochemistry. 31: 5022—5032. PMID 1534690.
- ^ Mueller, E.J., Meyer, E., Rudolph, J., Davisson, V.J. and Stubbe, J. (1994). „N5-Carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli”. Biochemistry. 33: 2269—2278. PMID 8117684.
- ^ Thoden, J.B., Kappock, T.J., Stubbe, J. and Holden, H.M. (1999). „Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily”. Biochemistry. 38: 15480—15492. PMID 10569930.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- 5-(carboxyamino)imidazole+ribonucleotide+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
