Fibrolaza
Fibrolaza (EC 3.4.24.72, fibrinolitička proteinaza, Agkistrodon contortrix contortrix metaloproteinaza, Agkistrodon contortrix contortrix venomna metaloproteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fibrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.72 | ||||||||
| CAS broj | 116036-70-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza -Ala14-Leu- u insulinskom B lancu i -Lys413-Leu- u Aalfa-lancu fibrinogena
Ovaj enzim je prisutan u venumu zmije Agkistrodon contortix contortix.
Reference
уреди- ^ Retzios, A.D. & Markland, F.S., Jr. (1988). „A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems”. Thromb. Res. 52: 541—552. PMID 3232124.
- ^ Guan, A.L., Retzios, A.D., Henderson, G.N. and Markland, F.S., Jr. (1991). „Purification and characterization of a fibrinolytic enzyme from venom of southern copperhead snake (Agkistrodon contortrix contortrix)”. Arch. Biochem. Biophys. 289: 197—207. PMID 1898066.
- ^ Randolph, A., Chamberlain, S.H., Chu, H.L.C., Retzios, A.D., Markland, F.S. (1992). „Jr. and Masiarz, F.R. Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix venom”. Protein Sci. 1: 590—600. PMID 1304358.
- ^ Loayza, S.L., Trikha, M., Markland, F.S., Riquelme, P. and Kuo, J. (1994). „Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities”. J. Chromatogr. B Biomed. Appl. 662: 227—243. PMID 7719479.
- ^ Retzios, A.D. & Markland, F.S. (1994). „Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basilicus basilicus: cleavage site specificity towards the α-chain of fibrin”. Thromb. Res. 74: 355—367. PMID 8085237.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
