Fluoroacetil-KoA tioesteraza
Fluoroacetil-KoA tioesteraza (EC 3.1.2.29) je enzim sa sistematskim imenom fluoroacetil-KoA hidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Fluoroacetil-KoA tioesteraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.2.29 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- fluoroacetil-KoA + H2O fluoroacetat + KoA
Fluoroacetat je ekstremno toksičan.
Reference уреди
- ^ Meyer, J.J.M., Grobbelaar, N., Vleggaar, R. and Louw, A.I. (1992). „Fluoroacetyl-coenzyme-A hydrolase-like activity in Dichapetalum cymosum”. J. Plant Physiol. 139: 369—372.
- ^ Huang, F., Haydock, S.F., Spiteller, D., Mironenko, T., Li, T.L., O'Hagan, D., Leadlay, P.F. and Spencer, J.B. (2006). „The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A”. Chem. Biol. 13: 475—484. PMID 16720268.
- ^ Dias, M.V., Huang, F., Chirgadze, D.Y., Tosin, M., Spiteller, D., Dry, E.F., Leadlay, P.F., Spencer, J.B. and Blundell, T.L. (2010). „Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK”. J. Biol. Chem. 285: 22495—22504. PMID 20430898.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Fluoroacetyl-CoA+thioesterase на US National Library of Medicine Medical Subject Headings (MeSH)
