Formilmetanofuran dehidrogenaza
Formilmetanofuran dehidrogenaza (EC 1.2.99.5, formilmethanofuran:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom formilmethanofuran:akceptor oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
Formilmetanofuran dehidrogenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.2.99.5 | ||||||||
CAS broj | 119940-12-4 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- formilmetanofuran + H2O + akceptor CO2 + metanofuran + redukovani akceptor
Ovaj molibdoprotein sadrži pterinski kofactor. Volfram može da zameni molibden. Ovaj enzim katalizuje reverzibilnu reakciju u metanogenim bakterijama, i učestvuje u metanogenezi iz CO2 kao i oksidaciji metil-koenzima M do CO2. Metil viologen može da deluje kao akceptor. Ovaj enzim takođe oksiduje N-furfurilformamid.
Reference
уреди- ^ Karrasch, M., Börner, G., Enssle, M. and Thauer, R.K. (1990). „The molybdoenzyme formylmethanofuran dehydrogenase from Methanosarcina barkeri contains a pterin cofactor”. Eur. J. Biochem. 194: 367—372. PMID 2125267.
- ^ Bertram, P.A., Schmitz, R.A., Linder, D. and Thauer, R.K. (1994). „Tungstate can substitute for molybdate in sustaining growth of Methanobacterium thermoautotrophicum. Identification and characterization of a tungsten isoenzyme of formylmethanofuran dehydrogenase”. Arch. Microbiol. 161: 220—228. PMID 8161283.
- ^ Bertram, P.A., Karrasch, M., Schmitz, R.A., Bocher, R., Albracht, S.P. and Thauer, R.K. (1994). „Formylmethanofuran dehydrogenases from methanogenic Archaea. Substrate specificity, EPR properties and reversible inactivation by cyanide of the molybdenum or tungsten iron-sulfur proteins”. Eur. J. Biochem. 220: 477—484. PMID 8125106.
- ^ Vorholt, J.A. & Thauer, R.K. (1997). „The active species of ’CO2’ utilized by formylmethanofuran dehydrogenase from methanogenic Archaea”. Eur. J. Biochem. 248: 919—924. PMID 9342247.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Formylmethanofuran+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)