GTP ciklohidrolaza I
GTP ciklohidrolaza I (EC 3.5.4.16, GTP ciklohidrolaza, guanozin trifosfatna ciklohidrolaza, guanozin trifosfat 8-deformilaza, dihidroneopterin trifosfatna sintaza, GTP 8-formilhidrolaza) je enzim sa sistematskim imenom GTP 7,8-8,9-dihidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| GTP ciklohidrolaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.5.4.16 | ||||||||
| CAS broj | 37289-19-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- GTP + H2O format + 7,8-dihidroneopterin 3'-trifosfat
Rreakcija se sastoji od hidrolize dve C-N veze i izomerizacije pentozne jedinice. Reciklizacija može da bude neenzimatska.
Reference
уреди- ^ Burg, A.W. & Brown, G.M. (1968). „The biosynthesis of folic acid. 8. Purification and properties of the enzyme that catalyzes the production of formate from carbon atom 8 of guanosine triphosphate”. J. Biol. Chem. 243: 2349—2358. PMID 4296838.
- ^ Wolf, W.A. & Brown, G.M. (1969). „The biosynthesis of folic acid. X. Evidence for an Amadori rearrangement in the enzymatic formation of dihydroneopterin triphosphate from GTP”. Biochim. Biophys. Acta. 192: 468—478. PMID 4904679.
- ^ Supangat, S., Choi, Y.K., Park, Y.S., Son, D., Han, C.D. and Lee, K.H. (2005). „Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61: 202—204. PMID 16510994.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- GTP+cyclohydrolase+I на US National Library of Medicine Medical Subject Headings (MeSH)
