Nitrazepam

Nitrazepam
IUPAC ime
	7-nitro-5-fenil-2,3-dihidro-1H-1,4-benzodiazepin-2-on
Klinički podaci
Prodajno ime	Alodorm, Apo-nitrazepam tablets BP, Apodorm, Benzalin
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	15-38 sati
Identifikatori
CAS broj	146-22-5
ATC kod	N05CD03 (WHO), N05CD02
PubChem	CID 4506
DrugBank	DB01595
ChemSpider	4350
KEGG	C07487
Hemijski podaci
Formula	C15H11N3O3
Molarna masa	281.2661
	SMILES [O-][N+](=O)C1=CC2=C(NC(=O)CN=C2C2=CC=CC=C2)C=C1; ;
	InChI InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19) ; Key:KJONHKAYOJNZEC-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	225 °C (437 °F)

Nitrazepam je benzodiazepinski derivat koji se koristi kao antikonvulsant i hipnotik.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Reference уреди

^ Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. PMID 2883820
^ Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. PMID 7782744
^ Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. PMID 2570451
^ Podhorna J, Krsiak M: Behavioural effects of a benzodiazepine receptor partial agonist, Ro 19-8022, in the social conflict test in mice. Behav Pharmacol. 2000 Apr;11(2):143-51. PMID 10877119
^ Nowakowska E, Chodera A: Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats. Pharmacol Biochem Behav. 1991 Feb;38(2):265-6. PMID 1676167
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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