Glicin amidinotransferaza

Glicin amidinotransferaza (EC 2.1.4.1, arginin-glicinska amidinotransferaza, arginin-glicinska transamidinaza, glicinska transamidinaza) je enzim sa sistematskim imenom L-arginin:glicin amidinotransferaza.[2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

Glicin amidinotransferaza
Amidinotransferase structure diagram.JPG
Stereo pogled na AGAT u standardnoj orijentaciji[1]
Identifikatori
EC broj2.1.4.1
CAS broj9027-35-4
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
L-arginin + glicin L-ornitin + guanidinoacetat

Ovaj enzim može da koristi kanavanine umesto arginina.

ReferenceУреди

  1. ^ Humm A, Fritsche E, Steinbacher S, Huber R (1997). „Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis”. EMBO J. 16 (12): 3373—85. PMC 1169963 . PMID 9218780. doi:10.1093/emboj/16.12.3373. 
  2. ^ Borsook, H. & Dubnoff, J.W. (1941). „The formation of glycocyamine in animal tissues”. J. Biol. Chem. 138: 389—403. 
  3. ^ Conconi, F. & Grazi, E. (1965). „Transamidinase of hog kidney. I. Purification and properties”. J. Biol. Chem. 240: 2461—2464. PMID 14304853. 
  4. ^ McGuire, D.M., Tormanen, C.D., Segal, I.S. and van Pilsum, J.F. (1980). „The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats, purification and some properties of rat kidney transamidinase”. J. Biol. Chem. 255: 1152—1159. PMID 6766137. 
  5. ^ Ratner, S. (1962). „Transamidination”. Ур.: Boyer, P.D., Lardy, H.; Myrb; auml; ck, K. The Enzymes. 6 (2nd изд.). New York: Academic Press. стр. 267—275. 
  6. ^ Ratner, S. & Rochovansky, O. (1956). „Biosynthesis of guanidinoacetic acid. I. Purification and properties of transamidinase”. Arch. Biochem. Biophys. 63: 277—295. PMID 13355454. 
  7. ^ Ratner, S. & Rochovansky, O. (1956). „Biosynthesis of guanidinoacetic acid. II. Mechanism of amidine group transfer”. Arch. Biochem. Biophys. 63: 296—315. PMID 13355455. 
  8. ^ Walker, J.B. (1956). „Biosynthesis of arginine from canavanine and ornithine in kidney”. J. Biol. Chem. 218: 549—556. PMID 13278360. 
  9. ^ Walker, J.B. (1957). „Studies on the mechanism of action of kidney transamidinase”. J. Biol. Chem. 224: 57—66. PMID 13398387. 

ЛитератураУреди

  • Ratner, S. (1962). „Transamidination”. Ур.: Boyer, P.D., Lardy, H.; Myrb; auml; ck, K. The Enzymes. 6 (2nd изд.). New York: Academic Press. стр. 267—275. 

Spoljašnje vezeУреди