Glikoprotein 3-a-L-fukoziltransferaza
Glikoprotein 3-a-L-fukoziltransferaza (EC 2.4.1.214, GDP-L-Fuc:N-acetil-beta-D-glukozaminid alfa1,3-fukoziltransferaza, GDP-L-Fuc:Asn-vezani GlcNAc alfa1,3-fukoziltransferaza, GDP-fukoza:beta-N-acetilglukozamin (Fuc to (Fucalfa1->6GlcNAc)-Asn-peptid) alfa1->3-fukoziltransferaza, GDP-L-fukoza:glikoprotein (L-fukoza na asparagin-vezani N-acetilglukozamin 4-N- {N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-(N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6))-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-N-acetil-beta-D-glukozaminil}asparagin) 3-alfa-L-fukozil-transferaza, GDP-L-fukoza:glikoprotein (L-fukoza na asparagin-vezani N-acetilglukozamin N4- {N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-(N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6))-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-N-acetil-beta-D-glukozaminil}asparagin) 3-alfa-L-fukozil-transferaza) je enzim sa sistematskim imenom GDP-beta-L-fukoza:glikoprotein (L-fukoza na asparagin-vezani N-acetilglukozamin N4- {N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-(N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6))-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-N-acetil-beta-D-glukozaminil}asparagin) 3-alfa-L-fukozil-transferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
Glikoprotein 3-a-L-fukoziltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.4.1.214 | ||||||||
CAS broj | 68247-53-0 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- GDP-beta-L-fukoza + N4-{N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-[N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6)]-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-N-acetil-beta-D-glukozaminil}asparagin GDP + N4-{N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->3)-[N-acetil-beta-D-glukozaminil-(1->2)-alfa-D-manozil-(1->6)]-beta-D-manozil-(1->4)-N-acetil-beta-D-glukozaminil-(1->4)-[alfa-L-fukozil-(1->3)]-N-acetil-beta-D-glukozaminil}asparagin
Za dejstvo ovog enzima je neophodan jon Mn2+.
Reference
уреди- ^ Wilson, I.B.H., Rendic, D., Freilinger, A., Dumic, J., Altmann, F., Mucha, J., Müller, S. and Hauser, M.-T. (2001). „Cloning and expression of α1,3-fucosyltransferase homologues from Arabidopsis thaliana”. Biochim. Biophys. Acta. 1527: 88—96. PMID 11420147.
- ^ Fabini, G., Freilinger, A., Altmann, F. and Wilson, I.B.H. (2001). „Identification of core α1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseradish peroxidase epitope”. J. Biol. Chem. 276: 28058—28067. PMID 11382750.
- ^ Leiter, H., Mucha, J., Staudacher, E., Grimm, R., Glössl, J. and Altmann, F. (1999). „Purification, cDNA cloning, and expression of GDP-L-Fuc:Asn-linked GlcNAc α1,3-fucosyltransferase from mung beans”. J. Biol. Chem. 274: 21830—21839. PMID 10419500.
- ^ van Tetering, A., Schiphorst, W.E.C.M., van den Eijnden, D.H. and van Die, I. (1999). „Characterization of core α1→3-fucosyltransferase from the snail Lymnaea stagnalis that is involved in the synthesis of complex type N-glycans”. FEBS Lett. 461: 311—314. PMID 10567717.
- ^ Staudacher, E., Altmann, F., Glössl, J., März, L., Schachter, H., Kamerling, J.P., Haard, K. and Vliegenthart, J.F.G. (1991). „GDP-fucose:β-N-acetylglucosamine (Fuc to (Fucα1→6GlcNAc)-Asn-peptide) α1→3-fucosyltransferase activity in honeybee (Apis mellifica) venom glands. The difucosylation of asparagine-bound N-acetylglucosamine”. Eur. J. Biochem. 199: 745—751. PMID 1868856.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Glycoprotein+3-alpha-L-fucosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)