Glikozilfosfatidilinozitolna fosfolipaza D
Glikozilfosfatidilinozitolna fosfolipaza D (EC 3.1.4.50, GPI-PLD, glikoproteinska fosfolipaza D, fosfatidilinozitolna fosfolipaza D, fosfatidilinozitol-specifična fosfolipaza D) je enzim sa sistematskim imenom glikoprotein-fosfatidilinozitol fosfatidohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glikozilfosfatidilinozitolna fosfolipaza D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.50 | ||||||||
| CAS broj | 113756-14-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 6-(alfa-D-glukozaminil)-1-fosfatidil-1D-mio-inozitol + H2O 6-(alfa-D-glukozaminil)-1D-mio-inozitol + 3-sn-fosfatidat
Ovaj enzim je takođe aktivan kad je O-4 glukozamina supstituisan oligosaharidom.
Reference уреди
- ^ Low, M.G. & Prasad, A.R.S. (1988). „A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma”. Proc. Natl. Acad. Sci. USA. 85: 980—984. PMID 3422494.
- ^ Malik, A.-S. & Low, M.G. (1986). „Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases”. Biochem. J. 240: 519—527. PMID 3028377.
- ^ Li, J.Y., Hollfelder, K., Huang, K.S. and Low, M.G. (1994). „Structural features of GPI-specific phospholipase D revealed by fragmentation and Ca2+ binding studies”. J. Biol. Chem. 269: 28963—28971. PMID 7961859.
- ^ Deeg, M.A, Vierman, E.L. and Cheung, M.C. (2001). „GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex”. J. Lipid Res. 42: 442—451. PMID 11254757.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Glycosylphosphatidylinositol+phospholipase+D на US National Library of Medicine Medical Subject Headings (MeSH)
