Glikoziltransferaza DesVII
Glikoziltransferaza DesVII (EC 2.4.1.277, DesVII) je enzim sa sistematskim imenom dTDP-3-dimetilamino-3,4,6-tridezoksi-alfa-D-glukopiranoza:10-dezoksimetinolid 3-dimetilamino-4,6-didezoksi-alfa-D-glukoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glikoziltransferaza DesVII | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.277 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- dTDP-3-dimetilamino-3,4,6-tridezoksi-alfa-D-glukopiranoza + 10-dezoksimetinolid dTDP + 10-dezoksimetimicin
DesVII je glikoziltransferaza odgovorna za dovanje TDP-D-desosamina na makrolaktone varijabilne veličine prstena.
Reference уреди
- ^ Borisova, S.A. & Liu, H.W. (2010). „Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway”. Biochemistry. 49: 8071—8084. PMID 20695498.
- ^ Borisova, S.A., Kim, H.J., Pu, X. and Liu, H.W. (2008). „Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications”. Chembiochem. 9: 1554—1558. PMID 18548476.
- ^ Hong, J.S., Park, S.J., Parajuli, N., Park, S.R., Koh, H.S., Jung, W.S., Choi, C.Y. and Yoon, Y.J. (2007). „Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation”. Gene. 386: 123—130. PMID 17049185.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Glycosyltransferase+DesVII на US National Library of Medicine Medical Subject Headings (MeSH)
