Glutamilna aminopeptidaza
Glutamilna aminopeptidaza (EC 3.4.11.7, aminopeptidaza A, aspartatna aminopeptidaza, angiotensinaza A, glutamilna peptidaza, Ca2+-aktivirana glutamatna aminopeptidaza, membranska aminopeptidaza II, antigen BP-1/6C3 mišjeg B limfocita, L-aspartatna aminopeptidaza, angiotensinaza A2) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Glutamilna aminopeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.11.7 | ||||||||
| CAS broj | 9074-83-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim aktiviraju joni Ca2+. On je najčešće vezan za membranu.
Reference
уреди- ^ Glenner, G.G., McMillan, P.J. and Folk, J.E. (1962). „A mammalian peptidase specific for the hydrolysis of N-terminal α-L-glutamyl and aspartyl residues”. Nature. 194: 867—867. PMID 13899213.
- ^ Chulkova, T.M. & Orekhovich, V.N. (1978). „Isolation and properties of aminopeptidase A from bovine kidneys”. Biokhimiya. 43: 964—969. PMID 508862.
- ^ Danielsen, E.M., Norén, O., Sjöström, H., Ingram, J. and Kenny, J. (1980). „Proteins of the kidney microvillar membrane. Aspartate aminopeptidase: purification by immunoadsorbent chromatography and properties of the detergent- and proteinase-solubilized forms”. Biochem. J. 189: 591—603. PMID 7011318.
- ^ Tobe, H., Kojima, F., Aoyagi, T. and Umezawa, H. (1980). „Purification by affinity chromatography using amastatin and properties of aminopeptidase A from pig kidney”. Biochim. Biophys. Acta. 613: 459—468. PMID 7448199.
- ^ Wu, Q., Lahti, J.M., Air, G.M., Burrows, P.D. and Cooper, M.D. (1990). „Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family”. Proc. Natl Acad. Sci. USA. 87: 993—997. PMID 1689065.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Glutamyl+aminopeptidase на US National Library of Medicine Medical Subject Headings (MeSH)
