Granzim B
Granzim B (EC 3.4.21.79, CTLA1, CCPII, citotoksna ćelijska proteinaza-1, granzim G, granzim H, CCP1 proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Granzim B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.79 | ||||||||
| CAS broj | 143180-74-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Preferentno odvajanje: -Asp- >> -Asn- > -Met-, -Ser-
Ovaj enzim je prisutan u citotoksičnim T limfocitnim granulama.
Reference уреди
- ^ Schmid, J. & Weissmann, C. (1987). „Induction of mRNA for a serine protease and a β-thromboglobulin-like protein in mitogen-stimulated human leukocytes”. J. Immunol. 139: 250—256. PMID 2953813.
- ^ Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C. (1991). „Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins”. Biochemistry. 30: 2217—2227. PMID 1998680.
- ^ Poe, M., Blake, J.T., Boulton, D.A., Gammon, M., Sigal, N.H., Wu, J.K. and Zweerink, H.J. (1991). „Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity”. J. Biol. Chem. 266: 98—103. PMID 1985927.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Granzyme+B на US National Library of Medicine Medical Subject Headings (MeSH)
