Hidroksiizouratna hidrolaza
Hidroksiizouratna hidrolaza (EC 3.5.2.17, HIUHaza, 5-hidroksiizouratna hidrolaza) je enzim sa sistematskim imenom 5-hidroksiizourat amidohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Hidroksiizouratna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.5.2.17 | ||||||||
| CAS broj | 255885-20-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 5-hidroksiizourat + H2O 5-hidroksi-2-okso-4-ureido-2,5-dihidro-1H-imidazol-5-karboksilat
Ova reakcija je prvi stupan konverzije 5-hidroksiizourata u S-alantoin.
Reference уреди
- ^ Raychaudhuri, A. & Tipton, P.A. (2003). „A familiar motif in a new context: the catalytic mechanism of hydroxyisourate hydrolase”. Biochemistry. 42: 6848—6852. PMID 12779339.
- ^ Raychaudhuri, A. & Tipton, P.A. (2002). „Cloning and expression of the gene for soybean hydroxyisourate hydrolase. Localization and implications for function and mechanism”. Plant Physiol. 130: 2061—2068. PMID 12481089.
- ^ Sarma, A.D., Serfozo, P., Kahn, K. and Tipton, P.A. (1999). „Identification and purification of hydroxyisourate hydrolase, a novel ureide-metabolizing enzyme”. J. Biol. Chem. 274: 33863—33865. PMID 10567345.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Hydroxyisourate+hydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
