Hlorambucil

Hlorambucil
Klinički podaci
Prodajno ime	Ambochlorin, Amboclorin, Ecloril, Elcoril
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	1,5 h
Izlučivanje	Renalno
Identifikatori
CAS broj	305-03-3
ATC kod	L01AA02 (WHO)
PubChem	CID 2708
DrugBank	DB00291
ChemSpider	2607
ChEBI	CHEBI:28830
ChEMBL	CHEMBL515
Hemijski podaci
Formula	C14H19Cl2NO2
Molarna masa	304,212
	SMILES OC(=O)CCCC1=CC=C(C=C1)N(CCCl)CCCl; ;
	InChI InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19) ; Key:JCKYGMPEJWAADB-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	65 °C (149 °F)

Hlorambucil je organsko jedinjenje, koje sadrži 14 atoma ugljenika i ima molekulsku masu od 304,212 Da.^[1]^[2]^[3]^[4]^[5]

Osobine уреди

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	1
Broj rotacionih veza	9
Particioni koeficijent^[6] (ALogP)	3,9
Rastvorljivost^[7] (logS, log(mol/L))	-4,6
Polarna površina^[8] (PSA, Å²)	40,5

Reference уреди

^ Rai, Kanti R.; Peterson, Bercedis L.; Appelbaum, Frederick R.; Kolitz, Jonathan; Elias, Laurence; Shepherd, Lois; Hines, John; Threatte, Gregory A.; Larson, Richard A.; Cheson, Bruce D.; Schiffer, Charles A. (2000). „Fludarabine Compared with Chlorambucil as Primary Therapy for Chronic Lymphocytic Leukemia”. New England Journal of Medicine. 343 (24): 1750—7. PMID 11114313. doi:10.1056/NEJM200012143432402.
^ Yang K, Tan J, Wu T: Alkylating agents for Waldenstrom's macroglobulinaemia. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006719. PMID 19160296
^ Foon, K. A.; Hallek, M. J. (2010). „Changing paradigms in the treatment of chronic lymphocytic leukemia”. Leukemia. 24 (3): 500—11. PMID 20033051. S2CID 11926931. doi:10.1038/leu.2009.266.
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura уреди

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze уреди

Chlorambucil

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Rai, Kanti R.; Peterson, Bercedis L.; Appelbaum, Frederick R.; Kolitz, Jonathan; Elias, Laurence; Shepherd, Lois; Hines, John; Threatte, Gregory A.; Larson, Richard A.; Cheson, Bruce D.; Schiffer, Charles A. (2000). „Fludarabine Compared with Chlorambucil as Primary Therapy for Chronic Lymphocytic Leukemia”. New England Journal of Medicine. 343 (24): 1750—7. PMID 11114313. doi:10.1056/NEJM200012143432402.

[2] Yang K, Tan J, Wu T: Alkylating agents for Waldenstrom's macroglobulinaemia. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD006719. PMID 19160296

[3] Foon, K. A.; Hallek, M. J. (2010). „Changing paradigms in the treatment of chronic lymphocytic leukemia”. Leukemia. 24 (3): 500—11. PMID 20033051. S2CID 11926931. doi:10.1038/leu.2009.266.

[4] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709  . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889  . PMID 18048412. doi:10.1093/nar/gkm958.

[6] Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.

[7] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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