Holesterol 24-hidroksilaza (EC 1.14.13.98, holesterol 24-monooksigenaza, CYP46, CYP46A1, holesterolna 24S-hidroksilaza, citohromna P450 46A1) je enzim sa sistematskim imenom holesterol,NADPH:kiseonik oksidoreduktaza (24-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Holesterol 24-hidroksilaza
Identifikatori
EC broj1.14.13.98
CAS broj213327-78-7&title= 50812-30-1, 213327-78-7
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
holesterol + NADPH + H+ + O2 (24S)-24-hidroksiholesterol + NADP+ + H2O

Ovaj enzim je hem-tiolatni protein (P-450). On takođe može da formira 25-hidroksiholesterol.

Reference

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  1. ^ Lund, E.G., Guileyardo, J.M. and Russell, D.W. (1999). „cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain”. Proc. Natl. Acad. Sci. USA. 96: 7238—7243. PMID 10377398. 
  2. ^ Mast, N., Norcross, R., Andersson, U., Shou, M., Nakayama, K., Bjorkhem, I. and Pikuleva, I.A. (2003). „Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain”. Biochemistry. 42: 14284—14292. PMID 14640697. 
  3. ^ Lund, E.G., Xie, C., Kotti, T., Turley, S.D., Dietschy, J.M. and Russell, D.W. (2003). „Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover”. J. Biol. Chem. 278: 22980—22988. PMID 12686551. 
  4. ^ Bogdanovic, N., Bretillon, L., Lund, E.G., Diczfalusy, U., Lannfelt, L., Winblad, B., Russell, D.W. and Björkhem, I. (2001). „On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells.”. Neurosci. Lett. 314: 45—48. PMID 11698143. 
  5. ^ Russell, D.W. (2003). „The enzymes, regulation, and genetics of bile acid synthesis”. Annu. Rev. Biochem. 72: 137—174. PMID 12543708. 

Literatura

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Spoljašnje veze

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