Idoksuridin je organsko jedinjenje, koje sadrži 9 atoma ugljenika i ima molekulsku masu od 354,099 Da.[1][2][3][4][5]

Idoksuridin
Idoxuridine - Idoxuridin.svg
Klinički podaci
Prodajno imeAntizona, Dendrid, Emanil, Heratil
Drugs.comMonografija
Način primenetopikalno, oftalmički
Identifikatori
CAS broj54-42-2 ДаY
ATC kodD06BB01 (WHO), S01AD01
PubChemCID 5905
DrugBankDB00249 ДаY
ChemSpider5694 ДаY
ChEBICHEBI:147675 ДаY
ChEMBLCHEMBL788 ДаY
Hemijski podaci
FormulaC9H11IN2O5
Molarna masa354,099
Fizički podaci
Tačka topljenja263 °C (505 °F)

OsobineУреди

Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 3
Broj rotacionih veza 2
Particioni koeficijent[6] (ALogP) -1,4
Rastvorljivost[7] (logS, log(mol/L)) -0,8
Polarna površina[8] (PSA, Å2) 99,1

ReferenceУреди

  1. ^ Seth AK, Misra A, Umrigar D: Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications. Pharm Dev Technol. 2004 Aug;9(3):277-89. PMID 15458233
  2. ^ Otto SE: Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7. PMID 10392098
  3. ^ Fauth E, Zankl H: Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56. PMID 10209337
  4. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  5. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 
  6. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  7. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  8. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

LiteraturaУреди

Spoljašnje vezeУреди

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