Jodid peroksidaza (EC 1.11.1.8, tiroidna peroksidaza, jodotirozinska dejodaza, jodinaza, jodoperoksidaza (hem tip), jodidna peroksidaza-tirozinska jodinaza, jodotirozinska dejodinaza, monojodotirozinska dejodinaza, tiroperoksidaza, tirozinska jodinaza, TPO) je enzim sa sistematskim imenom jod:vodonik-peroksid oksidoreduktaza.[1][2][3][4][5][6][7][8][9][10][11] Ovaj enzim katalizuje sledeću hemijsku reakciju

Jodid peroksidaza
Identifikatori
EC broj1.11.1.8
CAS broj9031-28-1
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBsum
(1) 2 jodid + H2O2 + 2 H+ dijodin + 2H2O
(2) [tiroglobulin]-L-tirozin + jodid + H2O2 [tiroglobulin]-3-jodo-L-tirozin + 2H2O
(3) [tiroglobulin]-3-jodo-L-tirozin + jodid + H2O2 [tiroglobulin]-3,5-dijodo-L-tirozin + 2H2O
(4) 2 [tiroglobulin]-3,5-dijodo-L-tirozin + H2O2 [tiroglobulin]-L-tiroksin + [tiroglobulin]-aminoakrilat + 2H2O
(5) [tiroglobulin]-3-jodo-L-tirozin + [tiroglobulin]-3,5-dijodo-L-tirozin + H2O2 [tiroglobulin]-3,5,3'-trijodo-L-tironin + [tiroglobulin]-aminoakrilat + 2H2O

Tiroidna peroksidaza katalizuje biosintezu tiroidnih hormona L-tiroksina i trijodo-L-tironina.

ReferenceУреди

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  7. ^ Virion, A., Courtin, F., Deme, D., Michot, J.L., Kaniewski, J. and Pommier, J. (1985). „Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions”. Arch. Biochem. Biophys. 242: 41—47. PMID 2996435. 
  8. ^ Rawitch, A.B., Pollock, G., Yang, S.X. and Taurog, A. (1992). „Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase”. Arch. Biochem. Biophys. 297: 321—327. PMID 1497352. 
  9. ^ Sun, W. & Dunford, H.B. (1993). „Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine”. Biochemistry. 32: 1324—1331. PMID 8448141. 
  10. ^ Taurog, A., Dorris, M.L. and Doerge, D.R. (1996). „Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase”. Arch. Biochem. Biophys. 330: 24—32. PMID 8651700. 
  11. ^ Ruf, J. & Carayon, P. (2006). „Structural and functional aspects of thyroid peroxidase”. Arch. Biochem. Biophys. 445: 269—277. PMID 16098474. 

LiteraturaУреди

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