Jodofenpropit

Jodofenpropit
Nazivi
	IUPAC naziv 3-(1H-imidazol-5-il)propil N'-[2-(4-jodofenil)etil]imidotiokarbamat
	Drugi nazivi 1-[3-(3H-imidazol-4-il)propiltio]-N'-[2-(4-jodofenil)etil]formamidin
Identifikacija
CAS broj	143407-29-8 ;
3D model (Jmol)	interaktivna slika;
MeSH	Iodophenpropit
PubChem C ID	3035746;
	SMILES C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I; ; ; ; ; ;
Svojstva
Hemijska formula	C15H19IN4S
Molarna masa	414,30763
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Jodofenpropit je histaminski antagonist koji se selektivno vezuje za histaminski H₃ receptor. Njegov ¹²⁵I radioobeležen oblik se koristi za mapiranje distribucije H₃ receptora u telu.^[3]^[4]

Reference уреди

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994). „Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain”. British Journal of Pharmacology. 113 (2): 355—62. PMC 1510107  . PMID 7834183.
^ Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). „Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit”. Naunyn-Schmiedeberg's archives of pharmacology. 362 (1): 60—7. PMID 10935534. doi:10.1007/s002100000227.