Jodotirozin dejodinaza
Jodotirozin dejodinaza (EC 1.22.1.1, jodotirozinska dehalogenaza 1, DEHAL1) je enzim sa sistematskim imenom NADP+:L-tirozin oksidoreduktaza (jodinacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Jodotirozin dejodinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.22.1.1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-tirozin + 2 NADP+ + 2 I- 3,5-dijodo-L-tirozin + 2 NADPH + 2 H+ (sveukupna reakcija)
- (1a) L-tirozin + NADP+ + I- 3-jodo-L-tirozin + NADPH + H+
- (1b) 3-jodo-L-tirozin + NADP+ + I- 3,5-dijodo-L-tirozin + NADPH + H+
Reakcija se odvija u smeru 3-dejodinacije. Ovaj enzim je transmembranski flavoprotein. Za njegovo dejstvo je neophodan FMN.
Reference
уреди- ^ Rosenberg, I.N. (1970). „Purification of iodotyrosine deiodinase from bovine thyroid”. Metabolism. 19: 785—798. PMID 4394169.
- ^ Gnidehou, S., Caillou, B., Talbot, M., Ohayon, R., Kaniewski, J., Noel-Hudson, M.S., Morand, S., Agnangji, D., Sezan, A., Courtin, F., Virion, A. and Dupuy, C. (2004). „Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site”. FASEB J. 18: 1574—1576. PMID 15289438.
- ^ Friedman, J.E., Watson, J.A., Jr., Lam, D.W. and Rokita, S.E. (2006). „Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily”. J. Biol. Chem. 281: 2812—2819. PMID 16316988.
- ^ Thomas, S.R., McTamney, P.M., Adler, J.M., Laronde-Leblanc, N. and Rokita, S.E. (2009). „Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands”. J. Biol. Chem. 284: 19659—19667. PMID 19436071.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Iodotyrosine+deiodinase на US National Library of Medicine Medical Subject Headings (MeSH)
