Kabozantinib
Kabozantinib (Cometriq) nespecifični inhibitor je tirozinskih kinaza c-Met i VEGFR2, koji redukuje rast tumora, metastazu, i angiogenezu. Odobren je 2012. On se koristi za lečenje metastatčkog medularnog tiroidnog kancera. Kabozantinib može da uzrokuje gastrointestinalne perforacije, fistule, i krvarenje.[1][2][3]
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| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Način primene | Oralno, oralno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 55 h |
| Izlučivanje | Fekalno (54%), renalno (27%). |
| Identifikatori | |
| CAS broj | 849217-68-1  |
| ATC kod | None |
| DrugBank | DB08875 |
| ChemSpider | 25948202 |
| ChEBI | CHEBI:72317 |
| Hemijski podaci | |
| Formula | C28H24FN3O5 |
| Molarna masa | 501.51 g mol |
| |
Reference уреди
- ^ Durante C, Russo D, Verrienti A, Filetti S: XL184 (cabozantinib) for medullary thyroid carcinoma. Expert Opin Investig Drugs. 2011 Mar;20(3):407-413. doi: 10.1517/13543784.2011.559163. PMID 21314233
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
Literatura уреди
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
