Katepsin L
Katepsin L (EC 3.4.22.15, Aldrichina grahami cisteinska proteinaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Katepsin L | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.15 | ||||||||
| CAS broj | 60616-82-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Slična reakcija sa reakcijom papaina. U poređenju sa katepsinom B, katepsin L je aktivniji na proteinskim supstratima, ali je manje aktivan na Z-Arg-Arg-NHMec
Ovaj lizozomalni enzim pripada peptidaznoj familoko C1 (papainskoj familiji).
Reference уреди
- ^ Barrett, A.J. & Kirschke, H. (1981). „Cathepsin B, cathepsin H and cathepsin L”. Methods Enzymol. 80: 535—561. PMID 7043200.
- ^ Barrett, A.J., Buttle, D.J. and Mason, R.W. (1988). „Lysosomal cysteine proteinases”. ISI Atlas of Science. Biochemistry. 1: 256—260.
- ^ Joseph, L.J., Chang, L.C., Stamenkovich, D. and Sukhatme, V.P. (1988). „Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts”. J. Clin. Invest. 81: 1621—1629. PMID 2835398.
- ^ Kirschke, H., Wikstrom, P. and Shaw, E. (1988). „Active center differences between cathepsins L and B: the S1 binding region”. FEBS Lett. 228: 128—130. PMID 3342870.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Cathepsin+L на US National Library of Medicine Medical Subject Headings (MeSH)
